ABSTRACT
Background: The fixed dose drug combinations (FDCs) of drugs is defined as product of two or more active ingredients in a defined composition. There is a need to study the pattern of prescription from time to time to evaluate their rationality. In this context we undertook this study to know the prescription pattern of FDC in our setting. To study the rationality of different prescribed FDCs.Methods: This is a prospective study which is carried out in NIMRA Institute of medical sciences which is a tertiary care teaching private hospital. For this study we have collected one thousand prescriptions of patients for 3 months that is from 10th March 2017 to 25th of June 2017 including both in-patients as well as outpatients. Selection criteria of patients mainly basing on their willingness to give prescriptions. Institutional ethical committee permission was taken for the study. The prescribed FDCs were compared with the essential drug list of FDCs approved by Drugs Controller General of India, July 2018. we have used descriptive statistics to analyze data. The percentage of FDCs used in each class and their contribution to overall FDCs were calculated.Results: In a total of 2952 drugs were prescribed, of this 747 were FDCs and 2205 were non FDCs. In the prescribed FDCs 89.2% drugs were rational and 10.8% drugs were irrational.Conclusions: From this study, we can conclude that 10.8% of irrational prescription of fixed dose drug combinations are prescribed in Nimra Institute of Medical Sciences which is a tertiary care teaching private hospital.
ABSTRACT
Background: Diabetes is a chronic metabolic disorder that continues to present a major worldwide health problem, characterized by absolute or relative deficiencies in insulin secretion and/or insulin action associated with chronic hyperglycaemia and disturbances of carbohydrate, lipid, and protein metabolism. It is fast growing disease, gains the status of a potential epidemic in India with prevalence of more than 62 million diabetic individuals currently diagnosed with the diabetes.Methods: The study was conducted at Department of Pharmacology, Kurnool Medical College, Kurnool for a period of 1 year from January 2017 to December 2018. Animals used were albino rats, of Wistar strain, weighing between 150-200gm of either sex. The animals were divided into six groups as: control group (I); pathogenic control group (II) injected intravenously (i.v.) with single dose of STZ (60mg/kg); Morus alba stem bark extract (group-III; 200mg/kg), and group-IV (400mg/kg); group-V animals treated with glibenclamide (5mg/kg, p.o.) following STZ treatment; group-VI, animals treated with bark extract per se (400 mg/kg).Results: The results of this study showed a significant decrease blood glucose level, glycosylated heamoglobin level, and reduction in glutathione and insulin level after STZ administration. These parameters were significantly (p<0.05) reversed by extracts dose dependently.Conclusions: Thus, authors conclude that M. alba stem bark extracts produced significant antidiabetic and antioxidant effect which might be due to the presence of bioactive components such as phenolic and flavonoid content in the extract. The study warrants the need for further evaluated in certain other models of diabetes.
ABSTRACT
Background: Peptic ulcer is very common disease. Peptic ulcer results probably due to an imbalance between aggressive factors (acid, pepsin, H. pylori) and defensive factors (gastric mucus, prostaglandins and bicarbonate secretion). Whatever may be the cause of peptic ulcer, it is the gastric acid that prevents ulcer healing and maintain the ulcer. Therefore, most of the drugs available for treatment of peptic ulcer either neutralize the secreted acid or decrease the acid secretion.Methods: The study was conducted on albino rats (Wistar) of 200-250g and maintained under standard conditions (room temperature 24-27oC and humidity 60-65%) with 12h light and dark cycle. The food in the form of dry pellets (Amrut Lab., hyd) and water were available ad libitum. The animal experiments were approved by the ethics committee of the institute.Results: In pyloric ligation model, the rats pre-treated with quercetin showed highly significant protection (p <0.001) when compared to control group and significant protection when compared to ranitidine pre-treated group (p <0.05). In indomethacin model, both quercetin and ranitidine pre-treated groups showed significant protection when compared to control group (p <0.01).Conclusions: In conclusion, it appears that quercetin possess anti-ulcerogenic principles like flavanoids, phenolic compound and caratinoid. These phytoconstituents provides protection against gastric mucosal damage induced by pylorus ligation, aspirin and ethanol, through inhibition of gastric acid, pepsin, histamine and free radical and stimulation of mucus secretion.